Heterocyclic steroid compounds

Details Heterocyclic steroid compounds Heterocyclic steroid compounds

1991-03-01

1993-06-15

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514461, 546 77, 544 23, 544 42, 544 83, 544384, 544461, 552540, 548426, C07J 7300, C07J 7500, A61K 3134, A61K 3138

Patent

active

052198790

ABSTRACT:
The present invention relates to novel substituted 15-oxa-, 15-thia-, and 15-aza- dihydrolanosterols, to pharmaceutical compositions containing such compounds, and to methods of using these compounds to suppress the activity of 3-hydroxy-3- methylglutaryl coenzyme A reductase (HMGR), an enzyme which is important in cholesterol biosynthesis. The overall effect of these heterocyclic lanosterol analogs is to decrease cholesterol formation, thereby resulting in lower serum cholesterol levels in mammals, and impaired ergosterol synthesis in fungi.

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