Des-proline vasopressin antagonists

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...

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2601125R, A61K 3700, C07C10352

Patent

active

044811934

ABSTRACT:
Certain octapeptides, which have structures characterized by being a six unit cyclic peptide ring with a dipeptide tail with no proline unit, have vasopressin antagonist activity. An important species of the group is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl-D-tyrosine)-4-valine]-7-desproline-8-arginine-vasopressin .

REFERENCES:
patent: 4367225 (1983-01-01), Manning et al.
patent: 4399125 (1983-08-01), Manning et al.

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