Method for restoring depleted purine nucleotide pools

Details Method for restoring depleted purine nucleotide pools Method for restoring depleted purine nucleotide pools

1988-03-11

1993-09-21

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 288, A61K 3170

Patent

active

RE0343870

ABSTRACT:
A method of increasing the rate of repletion of purine nucleotide pools in tissue deficient in the nucleotides, which comprises administering to a human or animal a therapeutically effective amount of 5-amino-4-imidazolecarboxamide riboside, 5-amino-4-imidazolecarboxamide, or a pharmaceutically acceptable salt thereof sufficient to increase the rate of the repletion is disclosed along with pharmaceutical compositions useful for carrying out the method of the invention.

REFERENCES:
patent: 3332935 (1967-07-01), Yamazaki et al.
patent: 3803126 (1974-04-01), Rousseau et al.
Toninello et al., Chem. Abstr., 80, P57898(e) (1973).
Atsuta et al., Chem. Abstr., 97, P124724(m) (1982).
Hasegawa et al., Chem. Abstr., 100, P3950(d) (1984, effective date 1982).
Cohen et al., Chem. Abstr., 100, P3958(n), effective date, 1983).
Lowy et al., Pediatr. Res., vol. 11, pp. 691-694 (1977).

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