Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1990-04-17
1991-12-10
Moezie, F. T.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530352, 530350, 514 8, 424 88, 424484, A61K 3710, C07K 1300
Patent
active
050719645
ABSTRACT:
A micelle of an adhesion protein which naturally includes a phosphatidylinositol lipid anchor, the micelle being capable of binding multivalently to a plurality of target molecules on a cell surface; where the adhesion protein is LFA-3, the LFA-3 micelles can be administered to a patient to inhibit binding of activated T-cells to other cells.
REFERENCES:
patent: 4578269 (1986-03-01), Morein
Sanchez-Madrid, Proc. Natl. Acad. Sci. USA, 79, 7489-7493, 1982.
Seed, "An LFA-3 cDNA Encodes a Phospholipidlinked Membrane Protein Homologous to Its Receptor CD2," Nature, 329: 840-842 (1987).
Dustin et al., "Anchoring Mechanisms for LFA-3 Cell Adhesion Glycoprotein at Membrane Surface", Nature, 329 846-848 (1987).
Wallner et al., "Primary Structure of Lymphocyte Function-Associated Antigen 3 (LFA-3) The Ligand of the T Lymphocyte CD2 Glycoprotein," J. of Experimental Medicine, 166: 923-932 (1987).
Caras et al., "Signal for Attachment of a Phospholipid Membrane Anchor in Decay Accelerating Factor," Science, 238: 1280-1283 (1987).
Tiefenthaler et al., "Purified Lymphocyte Function-Associated Antigen-3 and T11 Target Structure Are Active in CD2-Mediated T Cell Stimulation," Eur. J. Immunol. 17:1847-1850 (1987).
Detmers et al., "Aggregation of Complement Receptors on Human Neutrophils in the Absence of Ligand," The J. of Cell Biol., 105: 1137-1145 (1987).
Rosenberry et al., "Structure of Human Erythrocyte Acetylcholinesterase", The J. of Bio. Chem., 259: 5643-5652 (1984).
Hammarstrom, "Binding of Helix Pomatia A Hemagglutinin to Human Erythrocytes and Their Cells. Influence of Multivalent Interaction on Affinity," Scand. J. Immunol. 2: 53-66 (1973).
O'Flynn et al., "Different Pathways of Human T-Cell Activation Revealed by PHA-P and PHA-M," Immunology, 57: 55-60 (1986).
Hoessli et al., "Association of Specific Cell-Surface Glycoproteins with a Triton X-100-Resistant Complex of Plasma Membrane Proteins Isolated from T-Lymphoma Cells (P 1798), " Experimental Cell Research, 156: 239-250 (1985).
Dustin Michael
Springer Timothy
Dana-Farber Cancer Institute Inc.
Moezie F. T.
LandOfFree
Protein micelles does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Protein micelles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein micelles will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1041640