Process for the synthesis of 3',4'-dideoxykanamycin B and produc

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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424180, 536 17R, C07H 1522

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active

041560787

ABSTRACT:
A useful antibiotic, 3',4'-dideoxykanamycin B can be prepared in shortened steps and in an improved overall yield by a new process starting from kanamycin B via new intermediate derivatives of kanamycin B in which all the amino groups and possibly the 2"-hydroxyl group are protected with sulfonyl-type protecting groups selected from lower alkyl-, aryl- and aralkyl-sulfonyl groups.

REFERENCES:
patent: RE28647 (1975-12-01), Umezawa et al.
patent: 3868360 (1975-02-01), Daniels et al.
patent: 3929762 (1975-12-01), Umezawa et al.
Jikihara et al. Bulletin of the Chem. Soc. of Japan, vol. 46, pp. 3507-3510, 1973.
Umezawa et al., "Jour. of Antibiotics", vol. XXIV, No. 7, 1971, pp. 485-487.
Umezawa et al., "Jour. of Antibiotics", vol. XXV, No. 12, 1972, pp. 743-745.
Umezawa et al., "Bulletin of the Chem. Soc. of Japan", vol. 45, pp. 3624-3628, 1972.

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