Mixed baculovirus compositions and uses thereof

Details Mixed baculovirus compositions and uses thereof Mixed baculovirus compositions and uses thereof

1989-05-15

1991-12-10

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 4352351, 935 32, 935 34, 935 57, 935 60, 935 64, C12N 1586, C12P 2100

Patent

active

050717480

ABSTRACT:
A mixed composition polyhedral inclusion body (PIB) is provided which contains a mixture of nucleocapsids of at least two genetically distinct baculoviruses. At least one of the baculoviruses is genetically engineered to contain at least one heterologous gene. Followed ingestion of the mixed composition PIB by an insect host, a mixed viral infection ensues in the insect permitting the production therein of additional copies of the mixed composition PIB and the production of a heterologous protein encoded by the heterologous gene present in at least one of the baculoviruses.

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