Treatment of human retroviral infections with 2',3'-dideoxyinosi

Details Treatment of human retroviral infections with 2',3'-dideoxyinosi Treatment of human retroviral infections with 2',3'-dideoxyinosi

1990-01-03

1991-06-25

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 50, 514 43, 514 81, 514637, 536 23, 536 24, A61K 3170

Patent

active

050266870

ABSTRACT:
A preferred method and dosages for the short and long-term treatment of human retroviral infections, or retroviral-like infections, including acquired immunodeficiency syndrome (AIDS) and other manifestations of human immunodeficiency virus (HIV) infection, with 2',3'-dideoxyinosine (ddl) are disclosed, along with a protocol for halting and restarting 2',3'-dideoxyinosine to minimize certain side effects.

REFERENCES:
patent: 3817982 (1974-06-01), Verheyden et al.
patent: 4704357 (1987-11-01), Mitsuya et al.
patent: 4861759 (1989-08-01), Mitsuya et al.
Johnson et al., J. Biol. Chem., 263(30), 15354-15-357 (1988).
Lee et al., Antimicrobial Agents and Chemotherapy, 33(3), 336-339 (1989).
Tavares et al., Chem. Abstr., 110(23): 204,955q (6/6/89).
Hao et al., Chem. Abstr., 109(25): 222009t (12/19/88).

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