Scavenger antibody mixture and its use for immunometric assay

Details Scavenger antibody mixture and its use for immunometric assay Scavenger antibody mixture and its use for immunometric assay

1987-09-30

1991-06-25

Kepplinger, Esther L.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

436524, 436 65, 436165, 436807, 436814, 436818, 435 794, 435962, 422 58, 422 61, G01N 33543, G01N 3348, G01N 2108, G01N 148

Patent

active

050266535

ABSTRACT:
Provided is a test kit for conducting a membrane sandwich immunoassay of a multivalent antigen, optionally including reagents, the test kit includes a hollow container for reception of a fluid specimen, containing in series fluid absorbent body, a fluid pervious layer, and a fluid pervious solid membrane layer on which antibody is immobilized such that fluid added (e.g., labeled antibody and fluid specimen) to the container migrates through the membrane and in the presence of unlabeled scavenger antibody on the reactive surface of the membrane forms a multiple-site immunospecific antibody-antigen-antibody sandwich immobilized and labeled thereon, preferably in the form of a visible positive or negative indicator of the presence and/or amount of the analyte antigen in the specimen sample. The scavenger antibody serves to prevent false positive or other spurious reactions due to antigen analogs, antigen interference substances, or circulating human immnoglobulins.

REFERENCES:
patent: 4180556 (1979-12-01), Kim et al.
patent: 4299815 (1981-11-01), Hansen et al.
patent: 4514505 (1985-04-01), Canfield et al.
patent: 4595661 (1986-06-01), Cragle et al.
patent: 4737456 (1988-04-01), Weng et al.
patent: 4748042 (1988-05-01), Linnecke et al.

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