Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1988-11-16
1991-06-25
Warden, Robert J.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4351722, C12N 500, C12N 1500
Patent
active
050266462
ABSTRACT:
Stable heterohybridomas which secrete monoclonal antibodies to bovine herpesvirus-1 (BHV-1) are obtained by fusing primed bovine lymphocytes with an immortal cell line, selecting for secretial hybrids, and sequentially re-fusing such hybrids with fresh bovine lymphocytes. Three such heterohybridomas which secrete neutralizing antibody to BHV-1 have been obtained in this manner and have been deposited in the ATCC as Accession Nos. HB 9907, HB 9908, and HB 9909. The neutralizing antibodies are useful in immunological research, pathological diagnosis, and therapeutic disease control. Specifically, they have utility as serologic control reagents in assays, and as primary reagents in anti-species, anti-isotype, and anti-idiotypic antibody production.
REFERENCES:
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Nelson N. H. Teng et al., "Use of Heteromyelomas in the Enhancement of Human Monoclonal Antibody Production," In: Methods of Hybridoma Formation, ed. Arie H. Bartal et al., Humana Press, Clifton, NJ, 1987, pp. v, 257, 260-261; Human Hybridomas pp. 273, 282-283 (Kozbor et al.).
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Levings Randall L.
Stoll Ione R.
Fado John D.
Futrovsky Susan L.
Ribando Curtis P.
Silverstein M. Howard
The United States of America as represented by the Secretary of
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