Stable solvent adducts of Z-1-(p-.beta.-dimethylaminoethoxy-phen

Details Stable solvent adducts of Z-1-(p-.beta.-dimethylaminoethoxy-phen Stable solvent adducts of Z-1-(p-.beta.-dimethylaminoethoxy-phen

1988-04-19

1990-11-27

Gray, Bruce

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C21754

Patent

active

049737554

ABSTRACT:
This invention relates to new stereochemically pure and stable adducts of Z-1-(p-.beta.-dimethylaminoethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenyl-but- 1-ene and certain solvents which by virtue of their marked antioestrogenic activities may be used for the therapeutic treatment of benign breast diseases and hormone-dependent mammary tumors, in particularly by percutaneous application.

REFERENCES:
patent: 4198435 (1980-04-01), Richardson
patent: 4536516 (1985-08-01), Harper et al.
patent: 4623660 (1986-11-01), Richardson
P. C. Runitz et al, J. Med. Chem., 1982, 25, 1056-1060.
P. C. Runitz et al, Biochem. Pharmacol., 1983, 32, 2941.
Jordan et al, J. Endocr., vol. 75, pp. 305-316 (1977).

Affiliated with

Also associated with

Rating

Stable solvent adducts of Z-1-(p-.beta.-dimethylaminoethoxy-phen does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stable solvent adducts of Z-1-(p-.beta.-dimethylaminoethoxy-phen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stable solvent adducts of Z-1-(p-.beta.-dimethylaminoethoxy-phen will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1033002