Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1987-06-10
1990-11-27
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530350, 514 12, 424 9464, C07K 1300
Patent
active
049736680
ABSTRACT:
The invention relates to the variant of human alpha.sub.1 -antitrypsin of formula:
REFERENCES:
Shapira, M. et al., Chem. Abs. 104:125616c, Apr. 1986.
Davis, A. et al., Proc. Natl. Acad. Sci., U.S.A., 83, 3161-3165, May 1986.
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Synthesis in E. Coli of .alpha..sub.1 -Antitrypsin Variants of Therapeutic Potential for Emphysema and Thrombosis, Nature, vol. 313, No. 5998, Jan. 10, 1985, pp. 149-151.
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Recombinant Aplhal-Antitrypsin Pittsburgh (Met 358-Arg) is a Potent Inhibitor of Plasma Kallikrein and Activated Factor XII Fragment, Chemical Abstracts, vol. 104, No. 15, Apr. 1986, p. 316.
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Courtney Michael J.
Jallat Sophie
Perkins Susan M.
Schain Howard E.
Transgene S.A.
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