Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1982-05-03
1984-01-03
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2602393P, A61K 31535, C07D49806
Patent
active
044242190
ABSTRACT:
This invention relates to 9-thiomaytansinoid compounds represented by the formula ##STR1## wherein R is hydrogen or acyl derived from a carboxylic acid, X is chlorine or hydrogen, Y is hydrogen, lower alkylsulfonyl, or alkyl or aralkyl which are unsubstituted or substituted, and methods of producing the same. The compounds are useful as antitumor, antiprotozoal and antifungal agents.
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S. M. Kupchan et al., J. Med. Chem., 21, 31 (1978).
E. Higashide et al., Nature, 270, 721 (1977).
Hashimoto Naoto
Shimadzu Hiroshi
Bond Robert T.
Takeda Chemical Industries Ltd.
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