Process for the production of carnitine

Details Process for the production of carnitine Process for the production of carnitine

1975-09-25

1977-04-19

Evans, Joseph E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260482R, C07C10110, C07C10112

Patent

active

040188213

ABSTRACT:
The process for the production of carnitine hydrochloride which involves placing an ester of .gamma.-halo-acetoacetic acid having the formula: ##STR1## wherein R.sub.1 is hydrogen, R.sub.2 is a lower alkyl group having 1 to 10 carbon atoms and X is a halogen atom selected from the group consisting of chlorine or bromine, in an aqueous solution of excess trimethyl amine held at a temperature between 0.degree. and 50.degree. C., a reaction resulting between said ester and said amine. The excess trimethyl amine is distilled off. The pH of the solution is adjusted between 4 and 8, (3-carbalkoxy-2-oxopropyl)-trimethyl ammonium halide resulting. The (3-carbalkoxy-2-oxopropyl)-trimethyl ammonium is hydrogenated without isolating said halide from solution, a carnitine ester resulting. The carnitine ester is converted by means of aqueous hydrochloric acid into carnitine hydrochloride.

REFERENCES:
patent: 2530627 (1950-11-01), Pfister et al.
patent: 2933522 (1960-04-01), Cramer et al.
patent: 3038007 (1962-06-01), Reeve
patent: 3135788 (1964-06-01), Noguchi et al.
D'Alo et al., "Chem. Abstracts", vol. 60 (1964), cols. 10777, 10778.

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