Enzymatically hydrolyzable, serum-soluble cholesterol compounds

Details Enzymatically hydrolyzable, serum-soluble cholesterol compounds Enzymatically hydrolyzable, serum-soluble cholesterol compounds

1977-04-15

1980-01-15

Danison, Walter C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

23230B, 2601125R, 260121, 2603972, 424 2, 536 1, 536115, 562590, C07G 700, G01N 3316

Patent

active

041838475

ABSTRACT:
Water and serum soluble cholesterol compounds are prepared by reactively combining certain esters of cholesterol with a solubilizing agent selected from the group consisting of peptides, proteins, water soluble polycarboxylic acids, organic and inorganic water soluble salts of said polycarboxylic acids, and cis-vicinal water-soluble polysaccharides. The water-soluble cholesterol compounds can be lyophilized and added to serum as a standard for the determination of cholesterol in biological fluids either by traditional saponofication methods or by enzymatic methods.

REFERENCES:
patent: 3859043 (1975-01-01), Klein
patent: 4040784 (1977-08-01), Deshmukh
patent: 4042330 (1977-08-01), Deshmukh
Nauk, Chemical Abstracts, vol. 81:48,113p (1974).
Bell et al., J. Biol. Chem., vol. 251, No. 6, pp. 1745-1758 (1976).

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