Process for preparation of 1-benzylimidazole compound

Details Process for preparation of 1-benzylimidazole compound Process for preparation of 1-benzylimidazole compound

1989-09-06

1991-06-04

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23358

Patent

active

050215841

ABSTRACT:
Disclosed is a process for the preparation of a 1-benzylimidazole compound represented by the following general formula: ##STR1## wherein R.sub.2 represents a lower alkyl group or phenyl group, and R.sub.4 represents a hydrogen atom or a methyl group,
which comprises heating and to react a 1-unsubstituted imidazole compound represented by the following general formula: ##STR2## wherein R.sub.2 and R.sub.4 are as defined above, with benzyl alcohol in the presence of a carboxylic acid, a carboxylic anhydride, a benzyl ester thereof or a lower alkyl ester thereof, and neutralizing the reaction product with an alkali.

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