Permeable, non-irritating prodrugs of nonsteroidal and steroidal

Details Permeable, non-irritating prodrugs of nonsteroidal and steroidal Permeable, non-irritating prodrugs of nonsteroidal and steroidal

1994-10-05

1997-10-28

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549432, 552582, 560 56, 514463, 514573, 514530, C07D20942, C07J 500

Patent

active

056819641

ABSTRACT:
Prodrugs containing an active drug molecule linked to a polyethylene glycol group, and a method of use thereof are described. Exemplary soluble ester prodrugs contain naproxen, triamcinolone acetonide, gancyclovir, taxol, cyclosporin, dideoxyinosine, trihydroxy steroids, and flurbiprofen molecules linked to polyethylene glycol (PEG) groups. Pharmaceutical compositions containing these prodrugs, and a method of using these esters for treating disease states or symptoms are also described.

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patent: 4767751 (1988-08-01), Davis
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