New class of compounds having a variable spectrum of activities

Details New class of compounds having a variable spectrum of activities New class of compounds having a variable spectrum of activities

1989-05-30

1991-06-04

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514691, 549381, 549382, 560 75, A61K 3135, A61K 3112, C07D31178, C07C 6976

Patent

active

050214500

ABSTRACT:
The present invention relates to a new class of compounds having a variable spectrum of activities for capsaicin-like responses, compositions thereof, processes for preparing the same, and uses thereof. Compounds of the invention are prepared by combining phorbol related diterpenses and homovanillac acid analogs via esterification at the exocyclic hydroxy group of the diterpene. Examples of these compounds include 20-homovanillyl-mezerein and 20-homovanillyl-12-deoxyphorbol-13-phenylacetate.

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Schmidt et al, Phytochemistry, vol. 15, p. 1778 (1976).
Hayes et al, Life Sciences, 34, pp. 1241-1248 (1984).
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