Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1975-08-14
1976-09-14
Roberts, Elbert L.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
C07J 500
Patent
active
039806804
ABSTRACT:
21-Desoxy-17.alpha.-acyloxy-20-keto-4-pregnenes having physiological properties are prepared by the reaction of a 17.alpha.,21-dihydroxy-20-keto-4-pregnene 17.alpha.,21-orthoester or a 21-iodo-21-desoxy-17.alpha.-acyloxy-20-keto-4-pregnene with an iodide reagent selected from the group consisting of triphenylsilyl iodide, tri-lower alkylsilyl iodide and triphenylmethyl iodide. When said 17.alpha.,21-dihydroxy-20-keto-4-pregnene 17.alpha.,21-orthoester is reacted with less than two molar equivalents of a tri-lower alkylsilyl iodide reagent there is also formed a 21-iodo-21-desoxy-17-.alpha. -acyloxy-20-keto-4-pregnene, a useful intermediate, which, upon reaction with additional iodide reagent, is converted to the corresponding 21-desoxy-17.alpha.-acyloxy-20-keto-4-pregnene.
REFERENCES:
patent: 3796701 (1974-03-01), Cimaruste et al.
patent: 3798217 (1974-03-01), Ackrell et al.
King Mary S.
Roberts Elbert L.
Schering Corporation
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