Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-11-08
1997-10-28
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514375, 514443, 514394, 514465, 514464, 514469, 514415, 548178, 548217, 5483044, 548469, 549471, 549437, 549 51, C07D27762, C07D26356, C07D33354, C07D23508
Patent
active
056818424
ABSTRACT:
The present invention provides a compound of the formula: ##STR1## such compounds are useful for inhibiting prostaglandin synthesis. Pharmaceutical compositions and methods for inhibiting prostaglandin synthesis are also disclosed.
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Mitchell et al; Cyclooxygenase-2: Regulation and Relevance in Inflammation; Biochemical Pharmacology. vol. 50 No. 10 pp. 1535-1542, 1995.
Battistini et al; Cox-1 and Cox-2:"Toward the Development of More Selective Nsaids" (1994) Drug News and Perspectives, 7(8), 501-512.
DeWitt et al; The Differential Susceptibility of Prostaglandin Endoperoxide H Synthases-1 and -2 to Nonsteroidal Anti-Inflammatory Drugs: Aspirin Derivatives as Selective Inhibitors; Med Chem Res (1995) 5:325-343.
Dellaria Joseph F.
Gane Todd H.
Abbott Laboratories
Cross Laura R.
Dees Jos,e G.
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