Guanidinoalkyl glycine .beta.-amino acids useful for inhibiting

Details Guanidinoalkyl glycine .beta.-amino acids useful for inhibiting Guanidinoalkyl glycine .beta.-amino acids useful for inhibiting

1995-05-16

1997-10-28

Krass, Frederick

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 20, 514616, 514340, 514357, A61K 3700, C07K24100

Patent

active

056818203

ABSTRACT:
This invention herein relates to a method of treating a condition mediated by inhibition of .alpha..sub.v .beta..sub.3 integrins and a method of inhibiting tumor metastasis by administering a therapeutically effective amount of a compound having the following formula ##STR1## or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4879313 (1989-11-01), Tjeong et al.
patent: 4952562 (1990-08-01), Klein et al.
Fok et al. "Aminopeptidase resistant Arg-Gly-Asp analogs are stable in plasma inhibit platelet aggregation." Int. J. Peptide Res., 38, 124-130 (1991).
Greenspoon et al. "Structural Analysis of Integrin-Mediated Cell Functions by Novel Nonpeptide Surrogates of the Arg-Gly-Asp Sequence." Biochemistry, 32, 1001-1008 (1993).
McDowell et al. "From Peptide to Non-Peptide. The Elucidation of a Bioactive Conformation of the Arg-Gly-Asp Acid Recognition Sequence." J. Am. Chem. Soc., 116, 5069-5076 (1994).

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