Process for preparing methoxytrifluoromethylnaphthoic acid from

Details Process for preparing methoxytrifluoromethylnaphthoic acid from Process for preparing methoxytrifluoromethylnaphthoic acid from

1984-11-01

1985-12-31

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

570127, 570182, 562427, 562444, 562450, 260544B, 560 56, 560100, C07C 6334

Patent

active

045622868

ABSTRACT:
A multi-step process is described for preparing a methoxytrifluoromethylnaphthoic acid compound of formula ##STR1## from 1,5-dimethylnaphthalene and for preparing novel intermediate compounds of formula ##STR2## where X is chlorine or fluorine. Methoxytrifluoromethylnaphthoic acid is useful for preparing biologically active compounds such as naphthyl thioamide derivatives which inhibit aldose reductase activity.

REFERENCES:
Fung et al., Canadian Journal of Chem., vol. 61, pp. 368-371 (1982).

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