Treatment of shock

Details Treatment of shock Treatment of shock

1980-06-23

1981-12-29

Cacciapaglia, Jr., Frank

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

A61K 3122

Patent

active

043082807

ABSTRACT:
Pharmaceutical compositions for use in the relief of acute pulmonary edema, different types of shock including anaphylactic shock, shock induced by bacterial endotoxins, and hyperfibrinolysis induced by substances which activate plasminogen, consist of solutions of an ester of L-arginine with an aliphatic alcohol in water at a pH between 5.5 and 8.5. The compositions may be provided in unit dosage form containing 0.25-100 mg of active substance and are administered through the parenteral route. The esters may be provided in the form of a salt with a pharmaceutically acceptable organic or inorganic acid. The esters may be with methyl or ethyl alcohol. The compositions are more effective than aspirin and aprotinin.

REFERENCES:
Chem. Abstr., 8th Coll. Index, Subj. Index, p. 2910S & CA 71:91876v (1969).
Chem. Abstr., 8th Coll. Index, Subj. Index, p. 2910S & CA 70:45804B (1969).
Chem. Abstr., 9th Coll. Index, Subj. Index, p. 2215CS & CA 77:906q (1972).
Chem. Abstr., 9th Coll. Index, Subj. Index, p. 2215CS & CA 82:4588p (1975).
Chem. Abstr., 7th Coll. Index, Subj. Index, p. 2156S & CA 60:12300b (1964).
Chem. Abstr., 7th Coll. Index, Subj. Index, p. 2156S & CA 63:3237-8 (1965).
Feinberg et al., J. Pharmacol. & Exp. Therap., 99:195-201 (1950).
Rothschild et al., Arch. Pharmacol., 295:177-181 (1976).
Bertelli et al., Shock: Biochemical, Pharmacological & Clinical Aspects, vol. 9, pp. 215-225 (1969).
Hawiger et al., J. Lab. Clin. Med., pp. 93-108 (1970).

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