Process for preparing aminohydroxycephamcarboxylates

Details Process for preparing aminohydroxycephamcarboxylates Process for preparing aminohydroxycephamcarboxylates

1985-05-29

1987-03-03

Rosen, Sam

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540222, C07D50120

Patent

active

046476580

ABSTRACT:
A useful synthetic intermediate, 7-amino-3-acyloxycepham-4-carboxylic acid aralkyl ester, is prepared by reducing 7-amido-3-oxocepham-4-carboxylic acid aralkyl ester with alkali metal borohydride in a dry organic solvent at temperature lower than -20.degree. C. and then acylating the resulting 3-hydroxycepham compound with an acylating reagent to give 3-acyloxycepham compound, and then subjecting the 3-acyloxycepham compound to amide cleavage consisting of treatments (1) with a mixture of phosphorus pentachloride and aromatic base giving imino-chloride and (2) with alcohol for converting the latter into imino-ether and for subjecting the product to alcoholysis giving the objective compound.

REFERENCES:
patent: 3989695 (1976-11-01), Scartazzini

Affiliated with

Also associated with

Rating

Process for preparing aminohydroxycephamcarboxylates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing aminohydroxycephamcarboxylates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing aminohydroxycephamcarboxylates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1017526