Immunological adjuvant agents active in aqueous solution

Details Immunological adjuvant agents active in aqueous solution Immunological adjuvant agents active in aqueous solution

1976-08-25

1978-06-13

Shapiro, Lionel M.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, 424177, 2601125R, A61K 3902

Patent

active

040949710

ABSTRACT:
Immunological adjuvants obtainable from already-known water-soluble adjuvants containing peptidoglycane fragments, which include saccharide units formed from N-acetylglucosamine and from an N-acyl-muramic acid wherein the acyl group is a glycolyl or acetyl group and to the muramyl group there are attached peptide chains, by modification of said already-known water-soluble adjuvants so that they bear acylating groups derived from physiologically-acceptable carboxylic polyacids, especially carboxylic diacids, and wherein preferably the acylating groups themselves include free carboxylic acid groups, for instance being derived from phthalic acid or succinic acid.

REFERENCES:
patent: 3956481 (1976-05-01), Jolles et al.
patent: 4013788 (1977-03-01), Jolles et al.
patent: 4014992 (1977-03-01), Jolles et al.
patent: 4036953 (1977-07-01), Adam et al.
patent: 4042678 (1977-08-01), Ciorbaru et al.

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