Method for preparing 5-fluoroprostacyclins

Details Method for preparing 5-fluoroprostacyclins Method for preparing 5-fluoroprostacyclins

1985-01-25

1986-09-09

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549465, C07D307935

Patent

active

046110658

ABSTRACT:
This invention relates to a process for preparing 5-fluoroprostacyclins that are useful for the treatment of platelet dysfunction.

REFERENCES:
patent: 4324730 (1982-04-01), Fried
patent: 4472428 (1984-09-01), Toru et al.
patent: 4540801 (1985-09-01), Nysted et al.
R. A. Johnson, et al., "Synthesis and Stereochemistry of Prostacyclin and Synthesis of 6-Ketoprostaglandin F.sub.1.alpha. ", J. Am. Chem. Soc., 99, 4182-4184 (1977).
R. A. Johnson, et al., "The Chemical Structure of Prostaglandin X (Prostacyclin)," Prostaglandins, 12, 915-928 (1976).
C. Pace-Asciak and L. S. Wolfe, "A Novel Prostaglandin Derivative Formed from Arochidonic Acid by Rat Stomach Homogenates", Biochemistry, 10, 3657-3664 (1971).
W. E. Barnette, "The Synthesis and Biology of Fluorinated Prostacyclins," CRC Critical Reviews of Biochemistry, 15, 201-235 (1984).
B. Loev and M. M. Goodman, "Dry-Column Chromatography . . . ", Chemistry and Industry, 2026-2032 (1967).
R. A. Johnson, et al., "Synthesis and Characterization of Prostacyclin, 6-Ketoprostaglandin F.sub.1.alpha., Prostaglandin I.sub.1, and Prostaglandin I.sub.3," J. Am. Chem. Soc., 100, 7690-7704 (1978).
N. Whittaker, "A Synthesis of Prostacyclin Sodium Salt," Tetrahedron Lett., 2805-2808 (1977).

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