Antihypertensive pyridylaminobenzamide compounds

Details Antihypertensive pyridylaminobenzamide compounds Antihypertensive pyridylaminobenzamide compounds

1984-12-12

1986-09-09

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

540481, 540597, 514212, 514229, 514234, 514252, 514336, 514340, 514343, 514352, 544131, 544360, 546194, 546281, 546283, 546284, 546311, 546312, A61K 31445, C07D40112

Patent

active

046109919

ABSTRACT:
A series of 4-pyridinylaminobenzamides, useful as antihypertensive agents, was prepared from the corresponding 4-pyridinylaminobenzoic acids by reacting the acid chloride of the latter with ammonia or a primary or secondary amine. Alternatively the compounds were prepared by reacting an aminobenzamide with 4-chloropyridine or equivalent reagent.

REFERENCES:
patent: 3174972 (1965-03-01), Allais et al.
patent: 3226394 (1965-12-01), Schipper
patent: 3632761 (1972-01-01), Graham et al.
patent: 3875165 (1975-04-01), Archibald et al.
patent: 4241068 (1980-12-01), Schromm et al.
The Pharmacologist, vol. 25, No. 3, p. 101 (1983).
Ferrier, B., et al., Chemistry & Industry, 1089-1090 (1958).
Juby, P., et al., J. Med. Chem. 11, 111-117 (1968).
M. E. Konshin et al., (Perm. Gos. Farm. Inst., Perm, USSR) Deposited Document 1981, VINITI 2966-81 (Jun. 1, 1981) and sworn English translation.

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