Compartmentalized centrifugation chamber

Details Compartmentalized centrifugation chamber Compartmentalized centrifugation chamber

1984-08-17

1986-09-09

Bascomb, Wilbur

Chemical apparatus and process disinfecting, deodorizing, preser

Control element responsive to a sensed operating condition

422102, 494 16, 494 20, B01L 1100, B04B 502

Patent

active

046108467

ABSTRACT:
The stability of buoyant density gradients in centrifuge tubes decreases rapidly when the volume of the tubes is increased beyond 50-100 ml because vortices form in large tubes on acceleration and deceleration of the centrifuge. For large-scale density gradient separation of particles, e.g. blood cells, using centrifuge tubes it is therefore necessary to distribute the material into a number of small tubes. This time consuming procedure is simplified by using a compartmentalized centrifugation chamber subdivided by radially and vertically oriented walls or lamellae into a number of hydrostatically communicating compartments. The walls stabilize the large volume density gradient without interfering with sedimentation of the particles. As the compartments communicate, it is possible to layer and fractionate the density gradient in all compartments simultaneously, which results in a considerable reduction of time and labor required to separate large volumes of material by density gradient centrifugation.

REFERENCES:
patent: 817465 (1906-04-01), Bragg
patent: 3202348 (1965-07-01), Strohmaier
patent: 3456876 (1969-07-01), McEwen
patent: 4119407 (1978-10-01), Goldstein et al.
patent: 4129419 (1978-12-01), Hermann
patent: 4141489 (1979-02-01), Wright
patent: 4214993 (1980-07-01), Forsythe et al.
patent: 4435168 (1984-03-01), Kennedy
patent: 4439177 (1984-03-01), Conway

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