Hexahydroindolinzine compounds, pharmaceutical compositions and

Details Hexahydroindolinzine compounds, pharmaceutical compositions and Hexahydroindolinzine compounds, pharmaceutical compositions and

1984-08-02

1986-02-25

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514292, 546 84, 546 89, 546 80, 546114, 546115, 546121, C07D491147, C07D47114, C07D47104, C07D 3144

Patent

active

045729115

ABSTRACT:
Hexahydroindolizines of the following formulae (I) and (II): ##STR1## are novel and have been found to possess antisecretory and antidepressant properties. Methods of preparation, intermediates thereto and use are also disclosed.

REFERENCES:
patent: 4104390 (1978-08-01), Ferrand et al.
patent: 4315938 (1982-02-01), Schneider et al.
Maryanoff; B. E., "Stereochemistry of Intramolecular Amidoalkylation Reactions in the Synthesis of Polycyclic Isoquinoline Derivatives", J. Org. Chem., vol. 48, No. 25, (12/16/83), pp. 5062-5074.
Journal of Medicinal Chemistry, vol. 8, (1965), pp. 265-267, S. Wawzonek and J. D. Nordstrom.
Heterocycles, vol. 22, No. 1, 1984, "Synthesis of the New Tricyclic System Thieno[3',2':3,4]Pyrido[1,2-a]Pyrazine-4-One", Daniel Frehel and Jean-Peirre Maffrand.
Australian Journal of Chemistry, vol. 37, No. 2, 1984, pp. 367-379, "Synthesis of 4H-Thieno[2,3-d]azonine and Thieno[2,3-d]azecine Derivatives".
Journal of Organic Chemistry, ". . . Synthesis of Heterocyclic Amines", Winn and Zaugg, vol. 33, No. 10, pp. 3779-3783, (1968).

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