Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1983-08-15
1986-02-25
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
424 22, 424 31, 424 32, 424 33, 424 34, 424 35, 424 36, 424 37, 424 38, 424153, 427 3, A61K 922, A61K 948, A61K 950, A61K 954
Patent
active
045728330
ABSTRACT:
A pharmaceutical oral multiple-units composition with controlled release, in which the individual units are coated units of an active substance, e.g. potassium chloride, which is subject to controlled release in consequence of the units being coated with a substantially water-insoluble, but with a water-diffusable coating, is prepared by applying on units comprising the active substance, a film-forming coating mixture comprising a solvent, a film-forming substance dissolved in the solvent and a hydrophobic substance, such as a wax, e.g. a paraffin wax, the film coating mixture being applied at a temperature higher than the melting point of the hydrophobic substance. The application is preferably performed in a fluidized bed.
By thus incorporating a hydrophobic substance in the coating mixture in an amount of the order 1-25% in such a way that prior to the application, the hydrophobic substance is melted, but undissolved and microdispersed in the coating mixture, a coating is obtained which delays and controls the diffusion through the coating so that even easily soluble active substances, such as potassium chloride, can be slowly released.
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Jensen Jens R.
Pedersen Arne M.
A/S Alfred Benzon
Griffin Ronald W.
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