Novel alpha-chloroketone derivative and process for preparation

Details Novel alpha-chloroketone derivative and process for preparation Novel alpha-chloroketone derivative and process for preparation

1990-10-24

1991-08-20

Elmore, Carolyn S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564186, 548342, C07C32341, C07C32342

Patent

active

050416600

ABSTRACT:
Disclosed is a novel .alpha.-chloroketone derivative as a synthesis intermediate of N-cyano-N'-methyl-N"-(2-((5-methyl-1H-imidazol-4-yl)methylthio)ethyl)guani dine (general name: Cimetidine) which shows an action of controlling the secretion of gastric acid and is valuable as a medicine for remedy of a gastric ulcer. This .alpha.-chloroketone derivative is prepared by reacting disulfide derivative with sulfuryl chloride and reacting the reaction product with methylvinyl ketone or by reacting a mercapto derivative with 3-chloro-3-buten-2-one.

REFERENCES:
patent: 4814500 (1989-03-01), Kihara et al.
Wegner et al., Arch. Pharm., 310, 380-385 (1977).
Chemical Abstracts, 97:2687f (1982).

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