Aralkyl-4H-1,2,4-triazole derivatives

Details Aralkyl-4H-1,2,4-triazole derivatives Aralkyl-4H-1,2,4-triazole derivatives

1990-12-03

1991-09-03

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5482676, A61K 3141, C07D24908

Patent

active

050455567

ABSTRACT:
The invention relates to aralkyl-4H-1,2,4-triazole derivatives, especially 5-phenyl-lower alkyl-4H-1,2,4-triazole-3-carboxamides of the formula ##STR1## in which Ph represents phenyl substituted by lower alkyl, halogen and/or by trifluoromethyl, alky represents lower alkylidene, R.sub.1 is hydrogen or lower alkyl, and R.sub.2 represents carbamoyl that is unsubstituted or is substituted by lower alkyl or by lower alkanoyl, and their salts and, as the case may be, their tautomers and the salts thereof. These compounds can be used as anti-convulsive pharmaceutical active ingredients.

REFERENCES:
patent: 4209515 (1980-06-01), Heckendorn et al.
patent: 4209516 (1980-06-01), Heckendorn et al.
patent: 4789680 (1988-12-01), Meier
patent: 4851424 (1989-07-01), Allgeier
Grigg et al, "Heterocyclic Ring-Substituted Carboxamide and Methylamine Compounds and Compositions Containing Them", CA 96, 104249m (1981).
Tetrahedron, vol. 37, No. 24 pp. 4353-4356 (1981).
Chem. Abstr., vol. 96:217801d (1982).
J. Chem. Soc. Perkin Trans., vol. 1 pp. 761-764 (1977).

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