Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-04-04
1991-08-20
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 31535
Patent
active
050414410
ABSTRACT:
An inhibitor of glycosphingolipid metabolism is used as a chemotherapeutic agent against cancer or to treat other conditions caused by cell proliferation sensitive glycosphingolipid metabolism inhibition. A preferred inhibitor is 1-phenyl-2-acylamino-3-morpholino-1-propanol.
REFERENCES:
J. Inokuchi, I. Mason, and N. S. Radin, "Antitumor Activity Via Inhibition of Glycosphingolipid Biosynthesis", Cancer Letters, vol. 38, pp. 23-30, 1987.
J. Inokuchi and N. S. Radin, "Preparation of the Active Isomer of 1-Phenyl-2-Decanoylamino-3-Morpholino-1-Propanol, Inhibitor of Murine Glucocerebroside Synthetase", J. of Lipid Res., vol. 28, pp. 565-571, 1987.
F. Felding-Haberman, K. Handa, S. Hakomori and N. Radin, "Modulation of Lymphocyte Response and IL2-Dependent T Cell Proliferation by Gangliosides and their Derivatives and by Inhibitor of Ceramide Glycosylation", (abstract form), FASB Journal, vol. 2, p. A876, 1987.
S. Hakomori, "Glycosphingolipids", Scientific American, vol. 254, pp. 44-53, 1986.
K. S. Sundaram and M. Lev, "Inhibition of Sphingolipid Synthesis by Cycloserine In Vitro, and In Vivo:," J. of Neurochem., vol. 42, pp. 577-581, 1984.
R. R. Vunnam and N. S. Radin, "Analogs of Ceramide that Inhibit Glucocerbroside Synthetase in Mouse Brain", Chem. Phys. of Lipids, vol. 26, pp. 265-278, 1980.
R. R. Vunnam, D. Bond, R. A. Schatz, N. S. Radin and N. Narasimhachari, "A New Class of Monoamine Oxidase Inhibitors", J. of Neurochem., vol. 34, No. 2, pp. 410-416, 1980.
N. S. Radin and R. R. Vunnam, "Inhibitors of Cerebroside Metabolism", Methods of Enzymology, vol. 72, pp. 673-684, 1981.
K. R. Warren, R. S. Misra, R. C. Arora and N. S. Radin, "Glycosyltransferases of Rat Brain that Make Cerebrosides: Substrate Specificity, Inhibitors, and Abnormal Products", J. of Neurochem., vol. 26, pp. 1063-1072, 1976.
A. V. Hospattankar, R. R. Vunnam and N. S. Radin, "Changes in Liver Lipids after Administration of 2-Decanoylamino-3-Morpholinopropiophenone and Chlorpromazine", Lipids, vol. 17, No. 8, pp. 538-542, 1982.
S. C. Datta and N. S. Radin, "Glucosylceramide and the Level of the Glucosidase Stimulating Proteins", Lipids, vol. 21, No. 11, pp. 702-709, 1980.
Y. Shoenfeld, S. Berliner, J. Pinkhas and E. Beutler, "The Association of Gaucher's Disease and Dysproteinemias", Clin. Rev., vol. 64, pp. 241-243, 1980.
P. W. Pratt, S. Estren and S. Kochwa, "Immunoglobulin Abnormalities in Gaucher's Disease: Report of 16 Cases", Blood, vol. 31, No. 5, pp. 633-640, 1968.
Radin et al., Biochem. Pharmacol., 37:2879-2886 (1988) "Glucosphingolipids as Sites of Action in the Chemotherapy of Cancer".
Inokuchi Jin-ichi
Radin Norman S.
Goldberg Jerome D.
The Regents of the University of Michigan
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