Penetrating topical pharmaceutical compositions

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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424 47, 424 70, 514275, 514852, 514880, 514881, 514937, 514944, 514946, 514947, 514969, 5142358, A61K 706, A61K 912, A61K 3154, A61K 31535

Patent

active

050414399

ABSTRACT:
Topical pharmaceutical compositions containing a specific 6-amino-1,2-dihydro-1-hydroxy-2-iminopyrimidine component and a penetration-enhancing vehicle are disclosed. The vehicle comprises a binary combination of a C.sub.3 -C.sub.4 diol or C.sub.3 -C.sub.6 triol and isocetyl alcohol polar lipid compound. The vehicle provides marked transepidermal and percutaneous delivery of the iminopyrimidine compound. These compositions, when applied topically, act to stimulate the growth of mammalian hair on the body.

REFERENCES:
patent: 3382247 (1968-05-01), Anthony et al.
patent: 3535422 (1970-10-01), Cox et al.
patent: 4070462 (1978-01-01), Ecker
patent: 4139619 (1979-02-01), Chidsey
patent: 4299826 (1981-11-01), Luedders
patent: 4537776 (1985-08-01), Cooper
patent: 4557934 (1985-12-01), Cooper

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