Quinolone- and naphthyridonecarboxylic acid derivatives

Details Quinolone- and naphthyridonecarboxylic acid derivatives Quinolone- and naphthyridonecarboxylic acid derivatives

1995-09-27

1997-10-21

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514285, 514287, 514291, 514293, 514300, 514301, 514302, 546 61, 546 65, 546 80, 546 83, 546 89, 546 98, 546123, 546156, 546158, A61K 3147, C07D21514

Patent

active

056796897

ABSTRACT:
Disclosed are new quinolone- and naphthyridonecarboxyclic acid derivatives of the formula: ##STR1## wherein T represents a radical of the formula: ##STR2## and the other radicals are as disclosed herein, for example, the compound 7-(3a-amino-1,2,3,7a-tetrahydro-isoindol-2-yl)-1-cyclopropyl-6-fluoro-1,4- dihydro-8-methoxy-4-oxo-3-quinolinecarboxyclic acid, their salts, antibacterial compositions containing them, processes for their preparation, and methods of using them to combat bacterial infections. Disclosed also are intermediates useful in said processes of preparation.

REFERENCES:
patent: 5508278 (1996-04-01), Jaetsch et al.
Derwent Abstract of JP 04-253923 (1990) Week 9243, pp. 9-10.
M. Sato et al, J. Med. Chem., vol. 35, pp. 4745-4750 (1992).
P. Newman, "Optical Resolution Procedures for Chemical Compounds", vol. 1, Optical Resolution Information Center, Manhattan College, Riverdale, N.Y. (1978).
G. Blaschke, Angew. Chem. Int. Ed. Eng., vol. 19, pp. 13-24 (1980).

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