Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1994-11-21
1997-10-21
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514180, 514181, 514182, 514912, A61K 3133
Patent
active
056796668
ABSTRACT:
Methods and formulations for treating ocular neovascularization using angiostatic steroids are disclosed.
REFERENCES:
patent: 4771042 (1988-09-01), Braughler et al.
patent: 4876250 (1989-10-01), Clark
patent: 4975537 (1990-12-01), Aristoff et al.
Crum et al., A New Class of Steroids Inhibits Angiogenesis In The Presence of Heparin or Heparin Fragment, Science, 230 pp. 375-378 (Dec. 20, 1985).
Ingber, et al., A Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steroids: Induction of Capillary Basement Membrane Dissolution, Endocrinology 119, pp. 768-775 (1986).
Li, et al., Angiostatic Steroids Potentiated by Sulphated Cyclodextrin Inhibit Corneal Neovascularization, Investigative Ophthalmology and Visual Science, vol. 32, No. 11, pp. 2898-2905 (Oct., 1991).
Folkman, et al., Angiogenic Factors, Science, vol. 235, pp. 442-447 (1987).
Furcht, Critical Factors Controlling Angiogenesis: Cell Products, Cell Matrix, and Growth Factors, Laboratory Investigation, vol. 55, No. 5, pp. 505-509 (1986).
Cariou, et al., Inhibition of Human Endothelial Cell Proliferation by Heparin and Steroids, Cell Biology International Reports, vol. 12, No. 12, pp. 1037-1047 (Dec., 1988).
Tokida, et al., Production of Two Variant Laminin Forms by Endothelial Cells and Shift of Their relative Levels by Angiostatic Steroids, The Journal of Biological Chemistry, vol. 264, No. 30, pp. 18123-18129 (Oct. 25, 1990).
Maragoudakis, et al., Antiangiogenic Action of Hepar in Plus Cortisone is Associated with Decreased Collagenous Protein Synthesis in the Chick Chorioallantoic Membrane System, The Journal of Pharmacology and Experimental Therapeutics, vol. 251, No. 22, pp. 679-682 (1989).
Ashino-Fuse, et al., Medroxyprogesterone Acetate, An Anti-Cancer and Anti-Angiogenic Steroid, Inhibits the Plasminogen Activator in Bovine Endothelial Cells, Int. J. Cancer, 44, pp. 859-864 (1989).
BenEzra, Neovasculogenic Ability of Prostaglandins, Growth Factors, and Synthetic Chemoattractants, american Journal of Ophthalmology, vol. 86, No. 4, pp. 455-461, (Oct. 1978).
Alcon Laboratories Inc.
Fay Zohreh
Yeager Sally
LandOfFree
Prevention and treatment of ocular neovascularization by treatme does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Prevention and treatment of ocular neovascularization by treatme, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prevention and treatment of ocular neovascularization by treatme will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1006876