Surgery – Blood drawn and replaced or treated and returned to body
Patent
1989-12-21
1991-08-20
Rosenbaum, C. Fred
Surgery
Blood drawn and replaced or treated and returned to body
540145, A61M 3700
Patent
active
050410784
ABSTRACT:
The present invention demonstrates a method of photodynamic inactivation of viruses having a membranous envelope, such as Herpes simplex type 1 and Human immunodeficiency type 1 viruses. The method uses substituted sapphyrin compounds to effect viral deactivation during radiation with light at or near the absorption wavelength of the sapphyrin compound. A highly reactive species selectively toxic to infectious agents is produced.
One particular sapphyrin compound useful for the practice of the invention is 8,17-bis(carboxymethyl)-3,12,13,22-tetraethyl-2,7,18,23-tetramethylsapphyr in (Sapphyrin 2). The most preferred sapphyrin sapphyrin compound for the practice of the invention is 3,8,12,13,17,22-hexaethyl-2,7,18,23-tetramethylsapphyrin (Sapphyrin 1).
The method is particularly suitable for inactivation of viruses in blood and blood products.
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Harriman Anthony
Judy Millard M.
Maiya Bhaskar G.
Matthews J. Lester
Newman Joseph T.
Baylor Research Foundation, a nonprofit corporation of the State
Board of Regents , The University of Texas System
Rose Sharon
Rosenbaum C. Fred
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