Indole-,benzofuran-,and benzothiophene-containing lipoxygenase-i

Details Indole-,benzofuran-,and benzothiophene-containing lipoxygenase-i Indole-,benzofuran-,and benzothiophene-containing lipoxygenase-i

1992-01-21

1993-10-05

Siegel, Alan

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514415, 514418, 514419, 514469, 514470, 549 49, 549 51, 549 52, 549 54, 549 55, 549 57, 549 58, 549462, 549466, 549467, 548484, 548485, 548486, 548469, 548495, A61K 3138, A61K 3134, C07D20904, C07D33352

Patent

active

052505650

ABSTRACT:
Pro-drugs of potent 5-lipoxygenase inhibiting compounds comprise compounds of the formula ##STR1## in which A is an alkylene or alkenylene group, X is oxygen, sulfur, sulfoxyl, or substituted nitrogen, and Y is a group which includes substituted or unsubstituted carbocyclic or substituted or unsubstituted heterocyclic aryl. R.sup.1 is an alkyl, alkenyl, amino, alkylamino, dialkylamino, or hydroxyamino group or an amine group bearing a metabolically cleavable leaving group. M is hydrogen, a pharmaceutically acceptable cation or a metabolically cleavable leaving group, with the proviso that either M or R.sup.1 must bear a metabolically cleavable leaving group.

REFERENCES:
patent: 4873259 (1989-10-01), Summers et al.

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