Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-08-29
1993-10-05
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546269, 548525, 514422, A61K 3144, C07D40504
Patent
active
052505472
ABSTRACT:
Compounds of the Formula: ##STR1## wherein: R.sup.1 and R.sup.2 are independently hydrogen or lower alkyl, or when taken together with the carbon to which they are attached are cycloalkyl of 3 to 8 carbon atoms;
REFERENCES:
patent: 4975455 (1990-12-01), Brion et al.
patent: 5021432 (1991-06-01), Yanamaka et al.
patent: 5053523 (1991-10-01), Chandraratna
Potassium Channel Modulators, by Robertson et al., J. Med. Chem., 33, 1529-1541 (1990).
Relaxant Activity of 4-Amidobenzopyrans, by Buckle et al., J. Med. Chem., 33, 3028-3034 (1990).
Structure-Activity Relationships of K.sup.+ Channel Openers, by Edwards et al., Trends in Pharmacological Sciences, 11, 417-422 (1990).
Merck Index. 11th Edition pp. 1047-1048, 1989.
Wade Jr. Organic Chemistry p. 349, 1987.
Hicks Peter E.
Lochead Alistair W.
Navet Michel J.
Fan Jane T.
Lewis Brian
Lowin David A.
Moran Tom M.
Syntex (U.S.A.) Inc.
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