Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide
Patent
1995-06-07
1999-11-02
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fusion protein or fusion polypeptide
4241841, 4241851, 4241931, 530350, 530395, 530326, 514 14, A61K 3900
Patent
active
059765453
ABSTRACT:
A method for specifically inducing transient infertility or permanent sterility in a host animal by selective vaccination with specific zona pellucida proteins or immunocontraceptively active fragments thereof. Novel zona pellucida DNA sequences encoding specific zona pellucida proteins are disclosed.
REFERENCES:
patent: 4996297 (1991-02-01), Dunbar
patent: 5641487 (1997-06-01), Dean et al.
patent: 5820863 (1998-10-01), Dunbar
Colman et al. Research in Immunology. vol. 145: 33-36, 1994.
Chamberlin et al. P.N.A.S. vol. 87: 6014-6018, 1990.
Aitken et al., "Immunization against Zona Pellucida Antigens," Immunological Aspects of Reproduction and Fertility Control, Hearn, J., (ed.), MTP Press. Ltd. (1980).
Aitken et al., "The Influence of Anti-zona and Anti-sperm Antibodies on Sperm-egg Interactions," J. Reprod. Fert., 62:597-606 (1981).
Bleil et al., "Identification of a Secondary Sperm Receptor in the Mouse Egg Zona Pellucida: Role in Maintenance of Binding of Acrosome-Reacted Sperm to Eggs," Developmental Biology, 128:276-385 (1988).
Bleil et al., "Mammalian Sperm-Egg Interaction: Identification of Glycoprotein in Mouse Egg Zonae Pellucidae Possessing Receptor Activity for Sperm," Cell, 20:873-882 (1980).
Bleil et al., "Structure and Function of the Zona Pellucida: Identification and Characterization of the Proteins of the Mouse Oocyte's Zona Pellucida," Developmental Biology, 76:185-202 (1980).
Chamberlin et al., "Genomic Organization of a Sex Specific Gene: The Primary Sperm Receptor of the Mouse Zona Pellucida," Developmental Biology, 131:207-214 (1989).
Chamberlin et al., "Human Homolog of the Mouse Sperm Receptor," Developmental Biology, 87:6014-6018 (1990).
Dunbar et al., "Proteolysis of Specific Porcine Zona Pellucida Glycoproteins by Boar Acrosin," Biology of Reproduction, 32:619-630 (1985).
Dunbar et al., "Identification of the Three Major Proteins of Porcine and Rabbit Zonae Pellucidae by High Resolution Two-Dimensional Gel Electrophoresis: Comparison with Serum, Follicular Fluid, and Ovarian Cell Proteins," Biology of Reproduction, 24:1111-1124 (1981).
Hedrick et al., "Isolation of the Zona Pellucida and Purification of Its Glycoprotein Families from Pig Oocytes," Analytical Biochemistry, 157:63-70 (1986).
Hedrick et al., "On the Macromolecular Composition of the Zona Pellucida from Porcine Oocytes," Developmental Biology, 121:478-488 (1987).
Jones et al., "Histology of Ovaries of Female Rabbits Immunized with Deglycosylated Zona Pellucida Macromolecules of Pigs," J. Reprod. Fert., 95:513-525 (1992).
Keenan et al., "Endocrine Response in Rabbits Immunized with Native versus Deglycosylated Porcine Zona Pellucida Antigens," Biology of Reproduction, 44:150-156 (1991).
Kinloch et al., "Primary Structure of the Mouse Sperm Receptor Polypeptide Determined by Genomic Cloning," Proc. Natl. Acad. Sci., USA, 85:6409-6413 (1988).
Kinloch et al., "Genomic Organization and Polypeptide Primary Structure of Zona Pellucida Glycoprotein hZP3, the Hamster Sperm Receptor," Developmental Biology, 142:414-421 (1990).
Liang et al., "Oocyte-Specific Expression of Mouse Zp-2: Developmental Regulation of the Zona Pellucida Genes," Molecular and Cellular Biology, 10(4):1507-1515 (1990).
Mahi-Brown et al., "Fertility Control in the Bitch by Active Immunization with Porcine Zonae Pellucidae: Use of Different Adjuvants and Patterns of Estradiol and Progesterone Levels in Estrous Cycles," Biology of Reproduction, 32:761-722 (1985).
Maresh et al., "Antigenic Comparison of Five Species of Mammalian Zonae Pellucidae," The Journal of Experimental Zoology, 244:299-307 (1987).
Millar et al., "Vaccination with Synthetic Zona Pellucida Peptide Produces Long-Term Contraception in Female Mice," Science, 246:935-938 (1989).
Ringuette et al., "Molecular Analysis of cDNA Coding for ZP3, a Sperm Binding Protein of the Mouse Zona Pellucida, " Developmental Biology, 127:287-295 (1988).
Ringuette et al., "Oocyte-specific Gene Expression: Molecular Characterization of a cDNA Coding for ZP-3, the Sperm Receptor of the Mouse Zona Pellucida," Proc. Natl. Acad. Sci., USA, 83:4341-4345 (1986).
Sacco et al., "Application of a Radioimmunoassay (RIA) for Monitoring Immune Response to Porcine Zonae Pellucidae," Proceedings of the Society for Experimental Biology and Medicine, 167:318-326 (1981).
Sacco et al., "Carbohydrate Influences the Immunogenic and Antigenic Characteristics of the ZP3 Macromolecule (M.sub.r 55 000) of the Pig Zona Pellucida," J. Reprod. Fert., 76:575-586 (1986).
Schwoebel et al., "Isolation and Characterization of Full-length cDNA Encoding the 55-kDa Rabbit Zona Pellucida Protein," The Journal of Biological Chemistry., 266(11):7214-7219 (1991).
Skinner et al., Species Variation in the Zona Pellucida Immunological Approaches to Contraception and to Promotion of Fertility, GP Talwor, (Ed.), Plenum:New York, pp. 251-268 (1986).
Subramanian et al., "Specific Radioimmunoassay for the Detection of a Purified Porcine Zona Pellucida Antigen (PPZA)," Biology of Reproduction, 24:933-943 (1981).
Timmons et al., "Use of Specific Monoclonal and Polyclonal Antibodies to Define Distinct Antigens of the Porcine Zonae Pellucidae," Biology of Reproduction, 36:1275-1287 (1987).
Timmons et al., "Perspectives in Immunoproduction: Conception and Contraception," Mathur, S. and Fredericks, C.M., (eds.), Hemisphere Publishing Co., New York, pp. 242-260 (1988).
Wassarman, "Zona Pellucida Glycoproteins," Ann. Rev. Biochem., 57:415-442 (1988).
Wolgemuth et al., "Formation of the Rabbit Zona Pellucida and Its Relationship to Ovarian Follicular Development," Developmental Biology, 106:1-14 (1984).
Yurewicz et al., "Isolation and Preliminary Characterization of a Purified Pig Zona Antigen (PPZA) from Porcine Oocytes," Biology of Reproduction, 29:511-523 (1983).
Yurewicz et al., "Nucleotide Sequence of cDNA Encoding ZP3.alpha., a Sperm-binding Glycoprotein from Zona Pellucida of Pig Oocyte," Biochimica et Biophysica Acta., 1174:211-214 (1993).
Yurewicz et al., "Structural Characterization of the Mr= 55,000 Antigen (ZP3) of Porcine Oocyte Zona Pellucida," The Journal of Biological Chemistry, 262(2):564-571 (1987).
Chamow and Dean, "Anti-Zona Pellucida Antibodies in Mice Immunized With Recombinant ZP3-.beta.-Galactosidase Fusion Protein," Fed. Proc., 46(6):2015 (1988).
East, I.J., "Scintigraphy of Normal Mouse Ovaries with Monoclonal Antibodies to ZP-2, the Major Zona Pellucida Protein," Science, 225:938-941 (Aug. 31, 1984).
Lou and Tung, "T Cell Peptide of a Self-Protein Elicits Autoantibody to the Protein Antigen," J. of Immunology, 151:5790-5798 (1993).
Paterson et al., "Analysis of the Contraceptive Potential of Antibodies against Native and Deglycosylated Porcine ZP3 in Vivo and in Vitro," Biol. Reprod., 46(4):523-534 (Apr., 1992).
Rhim et al., "Autoimmune Disease of the Ovary Induced by a ZP3 Peptide from the Mouse Zona Pellucida," J. Clin. Invest., 89:28-35 (Jan., 1992).
Tung et al., "Autoimmune Disease of the Ovary: a Mechanism of Premature Ovarian Failure and a Complication of ZP3 Contraceptive Vaccine," Reprod. Immunol., 97:169-179 (1993).
Chamberlin and Dean, "Human Homolog of the Mouse Sperm Receptor," Proc. Nat'l Acad. Sci., USA, 87:6014-6018 (Aug., 1990).
Koyama et al., "Blocking of Human Sperm-Zona Interaction by Monoclonal Antibodies to a Glycoprotein Family (ZP4) of Porcine Zona Pellucida," Biology of Reproduction, 45:727-735 (1991).
Liu et al., "Contraception in Mares Heteroimmunized with Pig Zonae Pellucidae," J. Reprod. Fert., 85:19-29 (1989).
Henderson et al., "Contraceptive Potential of Antibodies to the Zona Pellucida," J. Reprod. Fert., 83:325-343 (1988).
Chamow et al. (1987) Fed Proc 46(6):2015.
Keenan et al. (1991) Biology of Reproduction vol. 44(1): 150-6.
Harris Jeffrey D.
Hsu Kuang T.
Podolski Joseph S.
Chan Christina Y.
Nolan Patrick J.
Zonagen, Inc.
LandOfFree
ZPC polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with ZPC polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and ZPC polypeptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2131565