Zonula occludens toxin receptor

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

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530326, 530412, 530413, 530825, 2041828, 435 71, 435909, 4242341, 4242611, 4242661, C07K 14705, C07K 14435, C07K 1400

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active

058640142

ABSTRACT:
A membrane-associate protein which is present on the surface of, inter alia, intestinal epithelia cells, is disclosed. The protein acts as a receptor for the zonula occludens toxin of Vibrio cholera, and is related to the modulation of intestinal tight junctions. Also disclosed are methods for the use of the same to screen for analogs of Vibrio cholera zonula occludens toxin.

REFERENCES:
patent: 5665389 (1997-09-01), Fasano
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Goding et al, In: Monoclonal Antibodies: Principles and Practice, pp. 219-240, London, Academic Press 1986.
Fiore et al, Gastroenterology, 110:A323 (1996).
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Ridley et al, Cell, 70:389-399 (1992).
Fiore et al. Gastroenterology May 19-22, 1996, vol. 110, No. 4, Abstract only.
Cuatrecasas et al. Methods in Enzymology. 1971, vol. XXII, pp. 345-355, 373-377.
Philp in the Protein Protocols Handbook ed. by John M. Walker 1996 Human Press, pp. 393-398.

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