Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1997-02-20
1999-01-26
Hutzell, Paula K.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530326, 530412, 530413, 530825, 2041828, 435 71, 435909, 4242341, 4242611, 4242661, C07K 14705, C07K 14435, C07K 1400
Patent
active
058640142
ABSTRACT:
A membrane-associate protein which is present on the surface of, inter alia, intestinal epithelia cells, is disclosed. The protein acts as a receptor for the zonula occludens toxin of Vibrio cholera, and is related to the modulation of intestinal tight junctions. Also disclosed are methods for the use of the same to screen for analogs of Vibrio cholera zonula occludens toxin.
REFERENCES:
patent: 5665389 (1997-09-01), Fasano
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Ridley et al, Cell, 70:389-399 (1992).
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Cuatrecasas et al. Methods in Enzymology. 1971, vol. XXII, pp. 345-355, 373-377.
Philp in the Protein Protocols Handbook ed. by John M. Walker 1996 Human Press, pp. 393-398.
Hutzell Paula K.
Masood Khalid
University of Maryland at Baltimore
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