ZNF206: regulator of embryonic stem cell self-renewal and...

Details ZNF206: regulator of embryonic stem cell self-renewal and... ZNF206: regulator of embryonic stem cell self-renewal and...

2008-08-06

2011-12-06

Noble, Marcia S (Department: 1632)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

C435S455000, C435S325000

Reexamination Certificate

active

08071378

ABSTRACT:
We have identified ZNF206, a novel repressor of human embryonic stem cell (hESC) differentiation. Repressing extra-embryonic endoderm development preserves the pluripotent state of human embryonic stem cells, and, conversely downregulating expression of ZNF206 in hESCs causes them to upregulate the expression of genes associated with the extra-embryonic endodermal lineage, down-regulate genes associated with the pluripotent state, and may lead to the further emergence of genes associated with even more differentiated lineages and phenotypes.

REFERENCES:
patent: 2007019398 (2007-02-01), None
Jaenisch and Young. Cell 132:567-582, 2008.
Stem Cells: Scientific Progress and Future Research Directions. Dept. of Health and Human Services. Jun. 2001. </info/scireport/2001report>. Chapter 1: The Stem Cell, pp. 1-4.
Zhang et al.: Nucleic Acids Research, vol. 34, No. 17, Oct. 2006, pp. 4780-4790.
Database UniProt [Online] Dec. 1, 2001, “RecName: Full=Zinc finger and SCAN domain-containing protein 10; AllName: Full=Zinc finger protein 206,” XP002589475 retrieved from EBI accession No. UNIPROT:Q96SZ4Database accession No. Q96SZ4.
Database UniProt [Online] May 2, 2006, “SubName: Full=ZSCAN10 protein; Flags: Fragment;” XP002589476 retrieved from EBI accession No. UNIPROT:Q1WWM2 Database accession No. Q1WWM2.
Database EMBL [Online] Feb. 3, 2004, “Sequence 759 from Patent W002068579.” XP002589477 retrieved from EBI accession No. EMBL:CQ714825 Database accession No. CQ714825.
Database EMBL [Online] Mar. 25, 2004, “Homo sapienszinc finger and SCAN domain containing 10, mRNA (eDNA clone IMAGE:4000761 0), partial cds.” XP002589478 retrieved from EBI accession No. EMBL:BC114452 Database accession No. BC114452.
Database EMBL [Online] May 15, 2001, “Homo sapienscDNA FLJ14549 fis, clone NT2RM2001670, weakly similar to Zinc Finger Protein 29.” XP002589479 retrieved from ESI accession No. EMBL:AK027455 Database accession No. AK027455.
Yu et al.: Journal of Biological Chemistry, vol. 284, No. 45, Nov. 2009, pp. 31327-31335.
Brandenberger et al: Nature Biotechnology, vol. 22. No. 6. Jun. 2004m oages 707-716.
Wang et al.: Journal of Biological Chemistry, vol. 282, No. 17, Apr. 2007, pp. 12822-12830.

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