Zinc-phthalocyanines and corresponding conjugates, their prepara

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514183, 514185, 540133, 540124, 540125, 540126, 540139, 540140, A61K 3140, C07D48722

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active

059655984

ABSTRACT:
The present invention refers to zinc-phthalocyanines of general formula (I) ##STR1## to processes for their preparation and to their use as phototherapeutic and photodiagnostic agents as free molecules and as conjugates with macromolecular carrier molecules.

REFERENCES:
patent: 5073295 (1991-12-01), Bruttel et al.
patent: 5192788 (1993-03-01), Dixon et al.
patent: 5281616 (1994-01-01), Dixon et al.
patent: 5427616 (1995-06-01), Tsuji et al.
patent: 5446141 (1995-08-01), Itoh et al.
European Search Report, Berlin, Dec. 17, 1998, Examiner Siatou, E.
J. Photochem. & Photobio., vol. 51, No. 3, 1990, pp. 351-356, D. Wohle, "thesis of positively charges phthalocyanines and their activity in the photodynamic therapy of cancer cells".
J. Photochem. & Photobio., vol. 32, No. 3, Feb. 1996, pp. 159-164, Minnock A et al. "Photoinactivation of Bacteria. Use of a Cationic Water-Soluble Zinc Phthalocyanine to Photoinactive both Gram-Negative and Gram-Positive Bacteria".
J. Photochem. * Photobio., vol. 37, No. 3, Feb. 1997, pp. 219-229, H. Dummin et al., "Selective photosensitization of mitochondria in HeLa cells by cationic Zn(II) phthalocyanines with lipophilic side chains".
Tetrahedron Letter, vol. 23, No. 30, 1982, pp. 3023-3026, C.C. Leznoff et al., "The Synthesis of a soluble, unsymmetrical phthalocyanine on a polymer support".
Dyes and Pigments, vol. 33, No. 1, Jan. 1997, pp. 65-78, Griffiths, J. et al., "Some Observations on the Synthesis of Polysubstituted Zinc Phthalocyanine Sensitisers for Photodynamic Therapy".
Patent Abstracts of Japan, vol. 97, No. 7, Jul. 31, 1997.
J. Photochem. & Photobio., vol. 65(3), 1997, pp. 397-402, Wood et al., "The Subcellular Localization of Zn(II)-Phthalocyanines and Their Exposure to Light".
J. Photochem. * Photobio., vol. 6, 1990, pp. 121-132, Rousseau et al., Biological Activities of Phthalocyanines XII+ Synthesis Tumor Uptake and Biodistribution of .sup.14 C-LAbeled Disulfonated and Trisulfonated Gallium Phthalogyanine in C3H Mice.
British Journal of Cancer, vol. 74, 1891-1899, C. Ometto et al., "Tumour-localising and -Photosensitising properties of a novel zinc(II) octadecylphthalocyanine".
SPIE, vol. 2078, 1993, pp. 106-118, Giulio Jori et al., "Photodynamic Therapy of Cancer".
Br. J. Surg., vol. 77, Jan. 1990, pp. 93-96, H. Barr et al. "Photodynamic Therapy for Colorectal Cancer: a quantitative pilot study".
J. Photochem. & Photobio., vol. 37, 1997, pp. 219-229, H. Dummin et al., "Selective Photosensitization of mitochondria in HeLa cells by cationic Zn(II)phthalocyanines with lipophilic side-chains".
Dyes and Pigments, vol. 18, 1992, pp. 91-102, Wohrle et al., "Efficient Synthesis of Phthalocyanines and Related Macrocyclic Compounds in the Presence of Organic Bases".
J. Photochem. & Photobio., vol. 36, 1996, pp. 87-93, Giulio Jori, "Tumour Photosensitizers: approaches to enchance the selectivity and efficiency of photocynamic therapy".
J. Photochem. & Photobio., vol. 49, No. 3, 1989, pp. pp. 279-284, C.C. Leznoff et al., "Synthesis and Photocytotoxicity of some new substituted phthalocyanines".
Seminars in Hematology, vol. 26, No. 1, Jan. 1989, pp. 27-34, Charles J. Gomer, "Photodynamic Therapy in the Treatment of Malignancies".
Int. J. Radiat. Biol., vol. 47, No. 2, 1985, pp. 145-147, Ehud Ben-Hur et al., "The phthalocyamins: a new class of mammalian cells photosensitizers with a potential for cancer phototherapy".
Rosenthal et al., Chem. Abst. vol. 108, 1988 108: 127680a.

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