Zinc finger binding domains for GNN

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07101972

ABSTRACT:
Zinc finger-nucleotide binding polypeptides having binding specificity for target nucleotides containing one or GNN triplets are provided. Compositions containing such polypeptides and the use of such polypeptides and compositions for regulating gene expression are also provided.

REFERENCES:
patent: 5096815 (1992-03-01), Ladner et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5789538 (1998-08-01), Rebar et al.
patent: 2002/0081614 (2002-06-01), Case et al.
patent: WO 91/07509 (1991-05-01), None
patent: WO 95/19431 (1995-07-01), None
patent: WO 96/06166 (1996-02-01), None
patent: WO 00/23464 (2000-04-01), None
Miller, et al., “Repetitive Zinc-Binding Domains in the Protein Transcription Factor IIIA from Xenopus Oocytes”EMBO J 4: 1609-1614 (1985).
Sadowski, et al., “Gal4-VP16 is an Unusually Potent Transcriptional Activator”,Nature 335: 563-564 (1988).
Lee, et al., “Three-Dimensional Solution Structure of a Single Zinc Finger DNA-Binding Domain”,Science 245: 635-637 (1989).
Pavletich, et al., “Zinc Finger-DNA Recognition: Crystal Structure of a Zi26B-DNA Complex at 2.1Å”,Science 252; 809-817 (1991).
Barbas, et al., “Assembly of Combinatorial Anibody Libraries on Phage Surfaces: The Gene III Site”,Proc. Natl. Acad. Sci. USA 88: 7978-7982 (1991).
Pavletich, et al., “Crystal Structure of a Five-Finger GLI-DNA Complex: New Perspectives on Zinc Fingers”,Science 261: 1701-1707 (1993).
Rebar, et al., “Zinc Finger Phage: Affinity Selection of Fingers with new DNA-Binding Specificities”,Science 263: 671-673 (1994).
Wu, et al., “Building Zinc Fingers by Selection: Toward a Therapeutic Application”,Proc. Natl. Acad. Sci. USA 92: 344-348 (1995).
Elrod-Erickson, et al., “Zi268 Protein-DNA Complex Refined at 1.6Å: A Model System for Understanding Zinc Finger-DNA Interactions”.
Kim, et al., “A 2.2.Å Resolution Crystal Structure of a Designed Zinc Finger Protein Bound to DNA”,Nature Structural Biology 3: 940-945 (1996).
Greisman, et al., “A General Strategy for Selecting High-Affinity Zinc Finger Proteins for Diverse DNA Target Sites”,Science 275: 657-661 (1997).
Design of TATA Box-Binding Protein/Zinc Finger Fusions for Targeted Regulation of Gene Expression,Proc. Natl. Acad. Sci. USA 94: 3616-3620 (1997).
Liu, et al., “Design of Polydactyl Zinc-Finger Proteins for Unique Addressing within Complex Genomes”,Proc. Natl. Acad. Sci. USA 94: 5525-5530 (1997).
Rader, et al., “Phage Display of Combinatorial Antibody Libraries”,Curr. Opin. Biotechnology R: 503-508 (1997).
Kim, et al., “Transcriptional Repression by Zinc Finger Peptides”,J. Biol. Chem. 272: 29795-29800 (1997).
Elrod-Erickson, et al., “High-Resolution Structures of Variant Zif268-DNA Complexes: Implications for Understanding Zinc Finger-DNA Recognition”,Structure 6: 451-464 (1998).
Beerli et al., “Toward Controlling Gene Expression at Will: Specific Regulation of theerbB-3/HER-2Promoter by Using Polydactyl Zinc Finger Proteins Constructed from Modular Building Blocks”,Proc, Natl. Acad. Sci. USA 95: 14628-14633 (1998).
Segal, et al., “Toward Controlling Gene Expression at Will: Selection and Design of Zinc Finger Domains Recognizing Each of the 5'-GNN-3' DNA Target Sequences”,Proc, Natl. Acad. Sci. USA 96: 2758-2763 (1999).
Gebelein, et al., “A Novel Profile of Expressed Sequence Tags for Zinc Finger Encoding Genes from the Poorly Differentiated Exocrine Pancreatic Cell Line AR4IP”,Cancer Letters105:225-231 (1996).
Liu, et al., “Design of Polydactyl Zinc-Finger Proteins for Unique Addressing within Complex Genomes”,Proc. Natl. Acad. Sci. USA 94: 5525-5530 (1997).
Ogawa, et al., “Enhanced Expression in Seminoma of Human Zinc Finger Genes Located on Chromosome 19”,Cancer Genet. Cytogenet, 100: 36-42 (1998).
Choo, et al., “Selection of DNA Binding Sites for Zinc Fingers using rationally randomized DNA reveals coded interactions”,Proc. Natl. Acad. Sci. USA 91: 11168-11172 (1994).
Choo, et al., “Toward a Code for the Interactions of Zinc Fingers with DNA: Selection of Randomized Fingers Displayed on Phage”,Proc. Natl. Acad. Sci. USA 91: 11163-11167 (1994).
Filippova, et al., “An Exceptionally Conserved Transcriptional Repressor, CTCF, Employs Different Combinations of Zinc Fingers to Bind Diverged Promoter Sequences of Avian and Mammalionc-nrcOncogenes”,Molecular and Cellular Biology 16 (6): 2802-2813 (1996).
Lee, et al., “Three Genes Encoding Zinc Finger Proteins on Human Chromosome 6p21.3: Members of a New Subclass of the Krüppel Gene Family Containing the Conserved SCAN Box Domain”,Genomics 43: 191-201 (1997).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Zinc finger binding domains for GNN does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Zinc finger binding domains for GNN, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Zinc finger binding domains for GNN will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3601021

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.