Zinc-doped tricalcium phosphate ceramic material

Compositions: ceramic – Ceramic compositions

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501123, 106 35, 424602, 424604, C01B 25222, A61F 228

Patent

active

060907320

ABSTRACT:
A tricalcium-phosphate-based prosthetic material is disclosed, which is a sintered ceramic body mainly consisting of tricalcium phosphate containing a limited amount of zinc, which is a known element having an osteogenesis-promoting effect, in the form of a solid solution. By virtue of the limited content of zinc and the form of solid solution in which zinc is contained, the inventive material exhibits an osteogenesis-promoting effect without toxicity. The ceramic body is prepared, preferably, by a process in which a tricalcium phosphate powder containing 0.015-8.00% by weight of zinc is diluted by the addition of hydroxyapatite and/or tricalcium phosphate free from zinc in such a proportion as to give a (Ca+Zn)/P molar ratio of 1.55 to 1.65 and the powder blend is shaped and subjected to sintering.

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M. Yamaguchi et al., Biochem. Pharm., 36(22), 4007-4012 (1987). no month.

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