Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Nucleoproteins – e.g. – chromatin – chromosomal proteins,...
Patent
1997-05-14
1999-09-28
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Nucleoproteins, e.g., chromatin, chromosomal proteins,...
4353201, 435325, 536 231, A61K 3816, C12N 1500, C12N 500, C07H 2102
Patent
active
059590815
ABSTRACT:
A substantially pure S2-6 protein (a) having a zinc binding LIM domain, (b) whose mRNA is preferentially expressed in nonproliferating or growth inhibited human diploid fibroblasts, (c) whose mRNA is overexpressed in senescent human diploid fibroblasts or human diploid fibroblasts derived from a patient with Werner Syndrome, and (c) whose mRNA expression is reduced or abolished in fetal human diploid fibroblasts, immortalized cells, cancerous cells and other highly proliferative cells.
REFERENCES:
Divecha, N. et al., Gene, vol. 156, pp. 283-286, 1995.
Adler Benjamin Aaron
The Board of Trustees of the University of Arkansas
Tung Peter P.
Wax Robert A.
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