Zinc-activated contrast agents

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C540S465000

Reexamination Certificate

active

07906105

ABSTRACT:
The present invention relates to contrast agents for magnetic resonance imaging (MRI). In particular, the present invention relates to MRI contrast agents that are activated in the presence of zinc(II) (e.g., resulting in a brighter image).

REFERENCES:
Meade et al. Current Opinion in Neurobiology, 2003, 2003, 13, 597-602.
Major et al. PNAS, 2007, 104(35), 13881-13886.
Hanaoka et al. Journal of the Chemical Society, PerkinTransactions 2, 2001, 1840-43.
Towner et al. (The Journal of Trace Elements in Experimental Medicine, 2004, 17, 161-174.
Bertini et al., “Nuclear spin relaxation in paramagnetic complexes of S=1: Electron spin relaxation effects,” J Chem Phys 1999, 11:5795-5807.
Bloemenbergen et al., “Proton Relaxation Times in Pramagnetic Solutions. Effects of Electron Spin Relaxation ,” J Chem Phys 1961, 34:842-850.
Bush, A. I., “The metallobiology of Alzheimer's disease,” Trends in Neurosciences 2003, 26:207-214.
Caravan et al., “Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications ,” Chem Rev 1999, 99:2293-2352.
Dadabhoy et al., “Long wavelength sensitizers for europium(III) luminescence base on acridone derivatives,” J Chem Soc 2002, 2:348-357.
Fredrickson et al., “Is zinc the link between compromises of brain perfusion (excitotoxicity) and Alzheimer's disease?” J Alzheimer's Disease 2005, 8:155-160.
Fredrickson et al., “The Neurobiology of Zinc in Health and Disease,” Nature Reviews 2005, 6:449-462.
Hanaoka et al., “Selective sensing of zinc ioins with a novel magnetic resonance imaging contrast agent,” J Chem Soc, Perkin Transactions 2 2001, 1840-1843.
Hanaoka et al., “Design and Synthesis of a Novel Magnetic Resonance Imaging Contrast Agent for Selective Sensing of Zinc Ion,” Chem Bio 2002, 9:1027-1032.
Hwang, L-P and Freed, J. H., “Dynamic effects of pair correlation functions on spin relaxation by translational . diffusion in liquids,” J Chem Phys 1975, 63(9):4017-4025.
Kikuchi et al., “Zinc sensing for cellular application,” Curr Opin Chem Bio 2004, 8:182-191.
Kruk et al., “Nuclear spin relaxation in paramagnetic systems with zero-field splitting and arbitrary electron spin,” Phys Chem Chem Phys 2001, 3:4907-4917.
Lauffer, R. S., “Paramagnetic Metal Complexes as Water Proton Relaxation Agents for NMR Imaging: Theory and Design,” Chem Rev 1987, 87:901-927.
Li et al., “A Calcium-Sensitive Magnetic Resonance Imaging Contrast Agent,” J Am Chem Soc 1999, 121:1413-1414.
Li et al., “Mechanistic Studies of a Calcium-Dependent MRI Contrast Agent,” Inorg Chem 2002, 41:4018-4024.
Louie et al., “In vivo visualization of gene expression using magnetic resonance imaging,” Nature Biotech 2000, 18:321-325.
Moats et al., “A ‘Smart’ Magnetic Resonance Imaging Agent that Reports on Specific Enzymatic Actvity,” Angew Chem Int Ed Engl 1997, 36:726-728.
Qian et al., “Imaging f Zn2+ Release from Pancreatic beta-Cells at the Level of Single Exocytotic Events,” Anal Chem 2003, 75:3468-3475.
Solomon, I, “Relaxation Processes in a System of Two Spins,” Phys Rev 1955, 99(2):559-565.
Stefanidou et al., “Zinc: a multipurpose trace element,” Arch Toxicol 2006, 80:1-9.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Zinc-activated contrast agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Zinc-activated contrast agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Zinc-activated contrast agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2723277

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.