Zero-order sustained release matrix tablet formulations of carba

Details Zero-order sustained release matrix tablet formulations of carba Zero-order sustained release matrix tablet formulations of carba

1998-01-23

1999-11-09

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424464, 424468, 424469, 424484, 424488, 424489, 424499, 424500, 424502, A61K 922, A61K 926

Patent

active

059809426

ABSTRACT:
A zero-order sustained-release delivery system for delivery of carbamazepine. A matrix tablet formulations of carbamazepine comprising hydrophilic polymer gel which inhibits transformation of carbamazepine into carbamazepine dihydrate by causing morphologic changes of carbamazepine crystals and results in amorphous form of carbamazepine present in the polymer matrix.

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Christopher F. Terrence, et al., Effect of Baclofen Enantiomorphs on the Spinal Trigeminal Nucleus and Steric Similarities of Carbamazepine, Pharmacology 27:85-94 (1983).
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Winnie Wai Ling et al., Kinetics of Transistion of Anhydrous Carbamazepine to Carbamazepine Dihydrate in Aqueous Suspensions, vol. 80, No. 5 pp. 496-500 (May 1991).
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