Zero-mode waveguides

Details Zero-mode waveguides Zero-mode waveguides

2007-02-20

2007-02-20

Healy, Brian M. (Department: 2883)

Optical waveguides

Planar optical waveguide

Thin film optical waveguide

C385S130000, C385S146000, C385S014000, C385S125000, C385S027000, C385S028000, C385S012000

Reexamination Certificate

active

11313971

ABSTRACT:
The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode waveguide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.

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