Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1990-12-07
1992-06-16
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
424 11, 424684, 424 4, 436173, 514836, 514974, 423328, G01N 3100, G01N 2400, C01B 3324, A61K 3306
Patent
active
051223635
ABSTRACT:
The invention relates to a method of using zeolite enclosed paramagnetic ions as image brightening or image contrast agents. In particular, zeolite enclosed trivalent gadolinium is useful in MRI studies of the entire gastrointestinal tract, providing excellent images. Zeolite-enclosed gadolinium complexes may be conveniently administered in oral preparations without side effects of diarrhea. Other transition metal ions, including divalent manganese may be enclosed in any suitable zeolite which has ion exchange properties sufficient to exchange the selected metal.
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Balkus, Jr. Kenneth J.
Sherry A. Dean
Young Stuart W.
Board of Regents , The University of Texas System
Hollinden Gary E.
Hollrah Glennon H.
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