Zearalanol derivatives with anabolic activity

Details Zearalanol derivatives with anabolic activity Zearalanol derivatives with anabolic activity

1987-10-13

1989-07-18

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549270, A61K 31335, C07D31300

Patent

active

048494470

ABSTRACT:
Compounds having the formula: ##STR1## wherein R.sub.1 is hydrogen, or an alkyl from about 1 to about 3 carbon atoms; R.sub.2 is hydrogen, or an alkyl from about 1 to about 18 carbon atoms; R.sub.3 is keto, or hydroxyl; and R.sub.4 is hydrogen, an alkyl from about 1 to about 4 carbon atoms, hydroxyl, or amino are synthesized and administered to animals as anabolic agents.

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patent: 3373038 (1968-03-01), Hodge et al.
patent: 3373039 (1968-03-01), Hodge et al.
patent: 3887583 (1975-06-01), Wehrmeister et al.
patent: 3957825 (1976-05-01), Urry et al.
patent: 4024602 (1977-08-01), Robertson et al.
patent: 4148808 (1979-04-01), Hodge
patent: 4239772 (1980-12-01), Shipchandler
patent: 4443470 (1984-04-01), Hodge et al.
Chemical Abstracts, vol. 69, No. 23, 96508v.
"Biodegradable Drug Delivery Systems", Wood, David A., Int. J. Pharm., 7, 1-18 (1980).
"Zearalenones: Characterization of Estrogenic Potencies and Receptor Interations of a Series of Fungal Beta-Resorcylic Acid Lactones", Katzenellenbogen et al., Endocrinology, 105: 33, 1979.

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